High-quality research needs high-quality devices and equipment. Advances in cellular and molecular biology studies have revolutionized the diagnosis and treatment of many different diseases. When it comes to diagnostics, a time-efficient high-quality diagnostic solution with software for cell counting and morphology, intracellular granules, cell counts and even protein expression levels.

When it comes to drug discovery processes, they are ideally combined with modern and innovative cell imaging techniques for high-throughput screening and imaging. Advances in computational sciences and machine learning algorithms have greatly served all biological sciences and allowed greater details to be dissected at a high throughput. From microbiology to immunooncology to cell culture, OLS provides you with your ideal imaging lab partner, the Hermes WiScan® High-Content Screening Workstation.

Hermes is a cost-effective High–Content / High–Throughput Screening system that operates at extremely high speeds of image acquisition and generates very high-quality images.

Whether you are performing assay development, compound screens, transfection assays or looking at a few samples in great detail, and whether you are using 3D models (such as spheroids, organoids), zebrafish imaging, primary cells, fixed cells or live-cell imaging, WiScan® Hermes is the solution for you.

High-Content Screening Workstation WiScan® Hermes

High-quality research needs high-quality devices and equipment. Advances in cellular and molecular biology studies have revolutionized the diagnosis and treatment of many different diseases. When it comes to diagnostics, a time-efficient high-quality diagnostic solution with software for cell counting and morphology, intracellular granules, cell counts and even protein expression levels.

When it comes to drug discovery processes, they are ideally combined with modern and innovative cell imaging techniques for high-throughput screening and imaging. Advances in computational sciences and machine learning algorithms have greatly served all biological sciences and allowed greater details to be dissected at a high throughput. From microbiology to immunooncology to cell culture, OLS provides you with your ideal imaging lab partner, the Hermes WiScan® High-Content Screening Workstation.

Hermes is a cost-effective High–Content / High–Throughput Screening system that operates at extremely high speeds of image acquisition and generates very high-quality images.

Whether you are performing assay development, compound screens, transfection assays or looking at a few samples in great detail, and whether you are using 3D models (such as spheroids, organoids), zebrafish imaging, primary cells, fixed cells or live-cell imaging, WiScan® Hermes is the solution for you.

Research in drug discovery is increasingly relying on 3D organoid and spheroid cell cultures due to their enhanced reliability as indicators of in vivo efficacy and toxicity. However, the challenges posed by the high cellular density and larger size of these cultures compared to traditional 2D cell cultures make automated image analysis during microscopy-based screening more complex.

Applying robust algorithms to combined brightfield and multicolor fluorescence imaging, advanced software has been developed to morphometrically characterize each spheroid in multiple channels. This innovative approach provides insights into multiple cell types within each culture system, revealing spatial distributions of individual, categorized cells.

Utilizing widefield microscopy ensures fast acquisition and high throughput capacity, meeting the demands of large-scale drug screening trials. The resulting analyses yield multi-parametric growth curves that not only identify variations in growth patterns but also describe perturbed physiology and cytotoxicity in multiplexed assays.

Building upon these capabilities, our advanced software not only addresses the complexities associated with 3D organoid and spheroid cell cultures but also offers a comprehensive suite of features tailored to enhance every stage of the drug discovery process:

• Capture properly focused images of spheroids in their ideal growth environment in U-shape bottom plates

• Easily spot Spheroids using unique methodology of rapid scanning for spheroid localization

• Simple and labour reducing automated analysis of spheroid relevant features

• Monitor Spheroid growth over the entire plate using plate view

• Classify Spheroids of specific, desired features using sub-population tool

• Apply Live/ Dead Spheroid Assay to monitor viability of 3D tumour spheroids

• Visualize spheroid morphology over a range of depths using flexible multi-plane definitions

• Monitor Spheroid growth over the entire plate

OMNI Life Science is proud to present Athena Zebrafish – the next generation in Zebrafish assays. Our new, unique dedicated analysis software for automated analysis of Zebrafish microscopy images offers simple and quick quantification of fluorescence, measurement of morphological changes & other phenotypic features in Zebrafish larvae in a high throughput format.

Athena Zebrafish is suited for a broad range of researchers and accepts multiple image format types output from nearly all microscope manufacturers.

The software permits parameter-free zebrafish analysis using simple bright-field images. It automatically detects zebrafish embryos and larvae up to 5 days old (days post fertilization), extracting the fish contour and much of its internal anatomy: yolk sac, eye, notocord, and more, along with body regions of the head, trunk, and tail.

For each of these objects, the software measures the morphology (area, length, and shape) and can detect fluorescence in associated color channels. Both fluorescence intensity and spot/structure detection within specific anatomy are supported.