Cardiac Tissue Model

Beating Cardiac Bodies – a complete workflow

Stem cell derived cardiomyocytes gain more and more attention in the field of cardiovascular research, disease modeling and drug development.

The CERO 3D Incubator & Bioreactor platform allows the workflow with stem cell expansion in homogeneous aggregates followed by direct induction into a high number of beating cardiac bodies. The expansion of pluripotent stem cells and subsequent cardiac induction/differentiation in CERO 3D results in a much higher cell quality, homogeneity, integrity and yield compared to traditional orbital shakers.

CERO 3D versus Orbital shaker – differentiation of murine embryonic stem cell derived cardiomyocytes 3, 8 and 13 days after cardiac induction.

  • Homogeneous 3D aggregates in suspension
  • Expansion and differentiation in the same CEROtube
  • Easy to handle & standardize
  • Highest yield
  • No substrate required
  • More relevance for drug treatments
  • More relevance for disease modeling

Purified and homogeneous cardiac bodies generated in CERO 3D Incubator & Bioreactor are a perfect tool for disease modeling and drug discovery. The pure cardiomyocytes can also be used in 2D downstream monolayer applications.

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